Another study showing psychedelics also decrease power of gamma brain waves

[5MeO-DMT_Philosopher]

https://www.nature.com/articles/s41398-021-01603-4

Human EEG studies with serotonergic psychedelics consistently report a broadband spectral power decrease (delta to gamma) most pronounced within the alpha band (8–12 Hz) and a decrease in functional connectivity and integrity of networks [21,22,23,24,25,26]. On the other hand, increases in higher frequencies (gamma oscillations, 30 Hz and above) have been also described [27,28,29]; however, the effects are hard to interpret due to typical contamination related to increased tension of the facial muscles. MEG, in contrast to EEG, is devoid of this contamination [30], and on the contrary shows a decrease in oscillations within the gamma range [31].

[Jim Cross]

But did the rats have a transformative experience? That's the real question.

[Martin_]

Thay should've had them Play Doom afterwards to see if there was a change in aggression.

[Dave casarino]

This study links to a study that tests psilocybin on human subjects https://www.jneurosci.org/content/33/38/15171.full using MEG, which isn't as easily contaminated by artifacts as EEG whilst essentially measuring the exact same thing, but in reverse (magnetism instead of electric), now here is the interesting part that any idealist following BK's argument would jump on in that unlike EEG readings with contaminated high gamma readings (high gamma being correlated to the highest mental function) MEG is not contaminated by that (but it has it's own problems, irrelevant in this though) and thus thus shows that GAMMA high and low also reduces..... but then it gets weird, quote "Moreover, excitation of deep-layer pyramidal cells is consistent with decreased brain activity (Carhart-Harris et al., 2012a) and oscillatory power because the net effect of feedback connections is thought to be inhibitory" and "Dynamic causal modeling revealed that posterior cingulate cortex desynchronization can be explained by increased excitability of deep-layer pyramidal neurons, which are known to be rich in 5-HT2A receptors. These findings suggest that the subjective effects of psychedelics result from a desynchronization of ongoing oscillatory rhythms in the cortex, likely triggered by 5-HT2A receptor-mediated excitation of deep pyramidal cells." then "This begins at the cellular level with excitation of layer 5 pyramidal neurons, and extends to the macroscopic level with cortical desynchronization and decreased brain network integrity. We postulate that this excitation occurs via stimulation of 5-HT2A receptors, which are densely expressed there" more importantly "Stimulation of the 5-HT2A receptor has been shown to enhance spontaneous EPSPs/EPSCs in neocortical layer 5 pyramidal cells by reducing outward potassium currents (Aghajanian and Marek, 1997; Lambe et al., 2000) and to cause increased glutamatergic recurrent activity in layer 5 of the cortex (Béïque et al., 2007). It is noteworthy that, while the decreases in spectral power seen here were broad, decreases in the alpha frequency were especially marked—particularly in the PCC where 5-HT2A receptors are densely expressed (Erritzoe et al., 2009). Layer 5 pyramidal cells fire with an intrinsic alpha rhythm (Silva et al., 1991; Sun and Dan, 2009) and spontaneous alpha oscillations are closely linked to perceptual processing, including processing of space and time (Lorincz et al., 2009; Klimesch, 2012). Thus, the marked decreases in alpha power observed here with psilocybin were likely due to interference with the intrinsic alpha oscillations of deep-layer pyramidal neurons via stimulation of 5-HT2A receptors, although we observed marked changes in spontaneous brain activity after psilocybin, but no effects on low-level induced gamma-band responses." and then there is this "Previous theoretical accounts of positive psychotic symptoms suggest that delusional thinking represents a failure of neural mechanisms to accurately encode predictions and prediction error or “surprise” (Corlett et al., 2010). In one prediction-coding model of global brain function based on the free-energy principle (Friston, 2010), activity in deep-layer projection neurons encodes top-down inferences about the world. Speculatively, if deep-layer pyramidal cells were to become hyperexcitable during the psychedelic state, information processing would be biased in the direction of inference—such that implicit models of the world become spontaneously manifest—intruding into consciousness without prior invitation from sensory data. This could explain many of the subjective effects of psychedelics." now these statements in the study place a mean paperweight against strong idealist claims, in that something else, namely deep pyramidal cells are being EXCITED by the psilocybin, and this EXCITEMENT (which means activity) unravels broadband synchronicity, so one thing goes down, but another thing goes UP.